ISWI and CHD chromatin remodelers bind to promoters but act in gene bodies
نویسندگان
چکیده
Background ATP-dependent nucleosome remodelers influence genetic processes by altering nucleosome occupancy, positioning, and composition. In vitro, yeast imitation switch (ISWI) and chromodomain helicase DNA-binding (CHD) remodelers bind ~30-85 bp of extranucleosomal DNA [1-3]. However, in vivo, ISWI and CHD remodelers act within gene bodies [4], which contain regularly spaced nucleosomes separated by less than 20 bp of linker DNA [5]. How, then, do ISWI and CHD remodelers act within regions containing insufficient linker DNA for their association with chromatin?
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